• Words of the Holy Father
• Celebration of Vespers and Te Deum in Thanksgiving for the past year (31 December 2021)
• Holy Mass on the Solemnity of the Nativity of the Lord (24 December 2021)
• Apostolic Journey to Cyprus and Greece: Holy Mass at “Megaron Concert Hall” in Athens (5 December 2021)
• Apostolic Journey to Cyprus and Greece: Holy Mass at the “GSP Stadium” in Nicosia (3 December 2021)
• Solemnity of Our Lord Jesus Christ, King of the Universe - Holy Mass (21 November 2021)
• Mass for the World Day of the Poor (14 November 2021)
• Holy Mass presided over by Pope Francis on the occasion of the 60th anniversary of the Faculty of Medicine and Surgery of the Catholic University of the Sacred Heart (Gemelli University Hospital, 5 November 2021)
• Holy Mass for the repose of the Cardinals and Bishops deceased during the course of the year (4 November 2021)
• Commemoration of all the faithful departed (French Military Cemetery, 2 November 2021)
• Holy Mass with Episcopal Ordinations (17 October 2021)
• Holy Mass - Opening of the Synodal Path (10 October 2021)
• Holy Mass celebrated for the Gendarmerie Corps of Vatican City State (2 October 2021)
• Mass with the Council of Bishops’ Conferences of Europe (23 September 2021)
• Apostolic Journey to Slovakia: Holy Mass on the esplanade of the National Shrine in Šaštin (15 September 2021)
• Apostolic Journey to Slovakia: Byzantine Divine Liturgy of Saint John Chrysostom presided by the Holy Father (14 September 20
• Apostolic Journey to Budapest: Holy Mass at Heroes' Square in Budapest (12 September 2021)
• Holy Mass - World Day for Grandparents and the Elderly (25 July 2021)
• Holy Mass and blessing of the Pallium for the new Metropolitan Archbishops on the Solemnity of Saints Peter and Paul (29 June 2021)
• Holy Mass on the Solemnity of the Most Holy Body and Blood of Christ (6 June 2021)
• Holy Mass on the Solemnity of Pentecost (23 May 2021)
• Holy Mass with the Myanmar Community in Rome (16 May 2021)
• Holy Mass with Priestly Ordinations (25 April 2021)
• Holy Mass on the Second Sunday of Easter, liturgical feast of Divine Mercy (11 April 2021)
• Easter Sunday - Mass of the Day (4 April 2021)
• Easter Vigil in the Holy Night of Easter (3 April 2021)
• Holy Chrism Mass (1 April 2021)
• Palm Sunday (28 March 2021)
• Holy Mass for the 500th Anniversary of the Evangelization of the Philippines (14 March 2021)
• Apostolic Journey to the Republic of Iraq: Holy Mass at the “Franso Hariri” Stadium in Erbil (7 March 2021)
• Apostolic Journey to the Republic of Iraq: Holy Mass at the Chaldean Cathedral of “Saint Joseph” in Baghdad (6 March 2021)
• Holy Mass, Blessing and Imposition of the Ashes (17 February 2021)
• Holy Mass on the 25th World Day For Consecrated Life (2 February 2021)
• Solemnity of the Conversion of Saint Paul - Celebration of Second Vespers (25 January 2021)
• Holy Mass on the occasion of the Sunday of the Word of God (24 January 2021)
• Holy Mass on the Solemnity of the Epiphany of the Lord (6 January 2021)
• Holy Mass on the Solemnity of Mary, Mother of God (1st January 2021)